[PDF][PDF] Hypusine: its post-translational formation in eukaryotic initiation factor 5A and its potential role in cellular regulation
MH Park, EC Wolff, JE Folk - BIOFACTORS-OXFORD THEN …, 1993 - researchgate.net
The amino acid, hypusine [N"-(4-amino-2-hydroxybutyl) lysine], a unique component of one
cellular protein, eukaryotic translation initiation factor 5A (eIF-5A, old terminology eIF-4D), is
formed post-translationally in two enzymatic steps:(i) transfer of the 4-aminobutyl moiety of
the polyamine spermidine to the e-amino group of a single specific lysine residue in the eIF-
5A precursor protein to form an intermediate, deoxyhypusine, and (ii) subsequent
hydroxylation in this 4-aminobutyl portion. Hypusine is produced soon after the translation of …
cellular protein, eukaryotic translation initiation factor 5A (eIF-5A, old terminology eIF-4D), is
formed post-translationally in two enzymatic steps:(i) transfer of the 4-aminobutyl moiety of
the polyamine spermidine to the e-amino group of a single specific lysine residue in the eIF-
5A precursor protein to form an intermediate, deoxyhypusine, and (ii) subsequent
hydroxylation in this 4-aminobutyl portion. Hypusine is produced soon after the translation of …