Proliferation of neural and neuronal progenitors after global brain ischemia in young adult macaque monkeys
AB Tonchev, T Yamashima, L Zhao, HJ Okano… - Molecular and Cellular …, 2003 - Elsevier
To investigate the effect of global cerebral ischemia on brain cell proliferation in young adult
macaques, we infused 5-bromo-2′-deoxyuridine (BrdU), a DNA replication indicator, into
monkeys subjected to ischemia or sham-operated. Subsequent quantification by BrdU
immunohistochemistry revealed a significant postischemic increase in the number of BrdU-
labeled cells in the hippocampal dentate gyrus, subventricular zone of the temporal horn of
the lateral ventricle, and temporal neocortex. In all animals, 20–40% of the newly generated …
macaques, we infused 5-bromo-2′-deoxyuridine (BrdU), a DNA replication indicator, into
monkeys subjected to ischemia or sham-operated. Subsequent quantification by BrdU
immunohistochemistry revealed a significant postischemic increase in the number of BrdU-
labeled cells in the hippocampal dentate gyrus, subventricular zone of the temporal horn of
the lateral ventricle, and temporal neocortex. In all animals, 20–40% of the newly generated …