Selecting against S1P3 enhances the acute cardiovascular tolerability of 3-(N-benzyl) aminopropylphosphonic acid S1P receptor agonists
JJ Hale, G Doherty, L Toth, SG Mills, R Hajdu… - Bioorganic & medicinal …, 2004 - Elsevier
JJ Hale, G Doherty, L Toth, SG Mills, R Hajdu, CA Keohane, M Rosenbach, J Milligan…
Bioorganic & medicinal chemistry letters, 2004•ElsevierSelecting against S1P3 enhances the acute cardiovascular tolerability of 3-(N-benzyl)aminopropylphosphonic
acid S1P receptor agonists - ScienceDirect Skip to main contentSkip to article Elsevier logo
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ScienceDirect Elsevier Bioorganic & Medicinal Chemistry Letters Volume 14, Issue 13, 5 July
2004, Pages 3501-3505 Bioorganic & Medicinal Chemistry Letters Selecting against S1P 3
enhances the acute cardiovascular tolerability of 3-(N-benzyl)aminopropylphosphonic acid …
acid S1P receptor agonists - ScienceDirect Skip to main contentSkip to article Elsevier logo
Journals & Books Search RegisterSign in View PDF Download full issue Search
ScienceDirect Elsevier Bioorganic & Medicinal Chemistry Letters Volume 14, Issue 13, 5 July
2004, Pages 3501-3505 Bioorganic & Medicinal Chemistry Letters Selecting against S1P 3
enhances the acute cardiovascular tolerability of 3-(N-benzyl)aminopropylphosphonic acid …
Structurally modified 3-(N-benzylamino)propylphosphonic acid S1P receptor agonists that maintain affinity for S1P1, and have decreased affinity for S1P3 are efficacious, but exhibit decreased acute cardiovascular toxicity in rodents than do nonselective agonists.
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