[HTML][HTML] Differential regulatory and compensatory responses in hematopoiesis/erythropoiesis in α-and β-globin hemizygous mice
H Beauchemin, MJ Blouin, M Trudel - Journal of Biological Chemistry, 2004 - ASBMB
Characterization of hematopoiesis/erythropoiesis in thalassemias from multipotent primitive
cells to mature erythrocytes is of fundamental importance and clinical relevance. We
investigated this process in α-and β-globin hemizygous mice, lacking the two adult tandemly
organized genes from either the α-or β-globin locus. Although both mice backcrossed on a
homogeneous background exhibited similar reduced red blood cell (RBC) survival, β-globin
hemizygous mice had less severe reticulocyte loss and globin chain imbalance, suggesting …
cells to mature erythrocytes is of fundamental importance and clinical relevance. We
investigated this process in α-and β-globin hemizygous mice, lacking the two adult tandemly
organized genes from either the α-or β-globin locus. Although both mice backcrossed on a
homogeneous background exhibited similar reduced red blood cell (RBC) survival, β-globin
hemizygous mice had less severe reticulocyte loss and globin chain imbalance, suggesting …