Common variants in the gene encoding ATP-binding cassette transporter 1 in men with low HDL cholesterol levels and coronary heart disease
ME Brousseau, M Bodzioch, EJ Schaefer… - Atherosclerosis, 2001 - Elsevier
HDL cholesterol (HDL-C) deficiency is the most common lipid abnormality observed in
patients with premature coronary heart disease (CHD). Recently, our laboratory and others
demonstrated that mutations in the ATP-binding cassette transporter 1 (ABCA1) gene are
responsible for Tangier disease, a rare genetic disorder characterized by severely
diminished plasma HDL-C concentrations and a predisposition for CHD. To address the
question of whether common variants within the coding sequence of ABCA1 may affect …
patients with premature coronary heart disease (CHD). Recently, our laboratory and others
demonstrated that mutations in the ATP-binding cassette transporter 1 (ABCA1) gene are
responsible for Tangier disease, a rare genetic disorder characterized by severely
diminished plasma HDL-C concentrations and a predisposition for CHD. To address the
question of whether common variants within the coding sequence of ABCA1 may affect …