Early studies have shown mitochondrially-mediated oxidative phosphorylation is diminished
in cancer cells, with glycolysis being the main source of energy production. More recent
provocative reports have indicated that the mitochondria may be involved in a host of
different aspects of tumorigenesis, including mutagenesis, maintenance of the malignant
phenotype, and control of apoptosis. These studies have broadened the possible roles
mitochondria may play in malignancy. Further studies to define the importance of …