Virus safety in xenotransplantation: first exploratory in vivo studies in small laboratory animals and non-human primates
V Specke, HJ Schuurman, R Plesker, C Coulibaly… - Transplant …, 2002 - Elsevier
For xenotransplantation, the transplantation of animal cells, tissues and organs into human
recipients, to date, pigs are favored as potential donors. Beside ethical, immunological,
physiological and technical problems, the microbiological safety of the xenograft has to be
guaranteed. It will be possible to eliminate all of the known porcine microorgansims in the
nearby future by vaccinating or specified pathogen-free breeding. Thus, the main risk will
come from the porcine endogenous retroviruses (PERVs) which are present in the pig …
recipients, to date, pigs are favored as potential donors. Beside ethical, immunological,
physiological and technical problems, the microbiological safety of the xenograft has to be
guaranteed. It will be possible to eliminate all of the known porcine microorgansims in the
nearby future by vaccinating or specified pathogen-free breeding. Thus, the main risk will
come from the porcine endogenous retroviruses (PERVs) which are present in the pig …