The role of matrix metalloproteinases in autoimmune damage to the central and peripheral nervous system
HP Hartung, BC Kieseier - Journal of neuroimmunology, 2000 - Elsevier
Members of the family of matrix metalloproteinases (MMPs) have been implicated in the
pathogenesis of inflammatory demyelination. MMPs apparently mediate important steps in
the genesis of inflammatory demyelination, such as cell migration, blood–brain/nerve barrier
breakdown, demyelination, and cytokine activation. This review will highlight in vitro as well
as in vivo findings, which support the importance of this group of proteases in the
pathogenesis of inflammatory demyelinating disorders of the central and peripheral nervous …
pathogenesis of inflammatory demyelination. MMPs apparently mediate important steps in
the genesis of inflammatory demyelination, such as cell migration, blood–brain/nerve barrier
breakdown, demyelination, and cytokine activation. This review will highlight in vitro as well
as in vivo findings, which support the importance of this group of proteases in the
pathogenesis of inflammatory demyelinating disorders of the central and peripheral nervous …