Lipopolysaccharide-induced HIV-1 expression in transgenic mice is mediated by tumor necrosis factor-α and interleukin-1, but not by interferon-γ nor interleukin-6
J Tanaka, H Ozaki, J Yasuda, R Horai, Y Tagawa… - Aids, 2000 - journals.lww.com
J Tanaka, H Ozaki, J Yasuda, R Horai, Y Tagawa, M Asano, S Saijo, M Imai, K Sekikawa…
Aids, 2000•journals.lww.comBackground As serum HIV-1 load correlates well with the prognosis of the disease, it is
suggested that the viral load is one of the major determinants of the disease progression of
AIDS. Accordingly, HIV-1 activation mechanisms were extensively studied in vitro, and
involvement of cytokines including tumor necrosis factor (TNF)-α, interleukin (IL)-1, IL-6 and
interferon (IFN)-γ has been suggested in this process. However, so far the roles of these
cytokines in the HIV-1 expression in vivo have not been well elucidated because of the lack …
suggested that the viral load is one of the major determinants of the disease progression of
AIDS. Accordingly, HIV-1 activation mechanisms were extensively studied in vitro, and
involvement of cytokines including tumor necrosis factor (TNF)-α, interleukin (IL)-1, IL-6 and
interferon (IFN)-γ has been suggested in this process. However, so far the roles of these
cytokines in the HIV-1 expression in vivo have not been well elucidated because of the lack …
Abstract
Background
As serum HIV-1 load correlates well with the prognosis of the disease, it is suggested that the viral load is one of the major determinants of the disease progression of AIDS. Accordingly, HIV-1 activation mechanisms were extensively studied in vitro, and involvement of cytokines including tumor necrosis factor (TNF)-α, interleukin (IL)-1, IL-6 and interferon (IFN)-γ has been suggested in this process. However, so far the roles of these cytokines in the HIV-1 expression in vivo have not been well elucidated because of the lack of appropriate animal disease models.
Objective
Lippincott Williams & Wilkins