Consequences of total and subtotal myeloperoxidase deficiency: risk or benefit?
D Kutter, P Devaquet, G Vanderstocken, JM Paulus… - Acta …, 2000 - karger.com
D Kutter, P Devaquet, G Vanderstocken, JM Paulus, V Marchal, A Gothot
Acta haematologica, 2000•karger.comA group of 100 totally or subtotally myeloperoxidase (MPO)-deficient individuals was
compared to a reference population of 118 probands selected at random. Data for a
protective effect of the deficiency against cardiovascular damage are presented. On the
other hand, a significantly higher occurrence of severe infections and chronic inflammatory
processes was noted among the deficient patients. An increased incidence of cancer among
the MPO-deficient individuals was not demonstrated.
compared to a reference population of 118 probands selected at random. Data for a
protective effect of the deficiency against cardiovascular damage are presented. On the
other hand, a significantly higher occurrence of severe infections and chronic inflammatory
processes was noted among the deficient patients. An increased incidence of cancer among
the MPO-deficient individuals was not demonstrated.
Abstract
A group of 100 totally or subtotally myeloperoxidase (MPO)-deficient individuals was compared to a reference population of 118 probands selected at random. Data for a protective effect of the deficiency against cardiovascular damage are presented. On the other hand, a significantly higher occurrence of severe infections and chronic inflammatory processes was noted among the deficient patients. An increased incidence of cancer among the MPO-deficient individuals was not demonstrated.
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