[HTML][HTML] Hypochlorite-modified high density lipoprotein, a high affinity ligand to scavenger receptor class B, type I, impairs high density lipoprotein-dependent selective …
G Marsche, A Hammer, O Oskolkova… - Journal of Biological …, 2002 - ASBMB
Hypochlorous acid/hypochlorite (HOCl/OCl−), a potent oxidant generated in vivo by the
myeloperoxidase-H 2 O 2-chloride system of activated phagocytes, alters the physiological
properties of high density lipoprotein (HDL) by generating a proatherogenic lipoprotein
particle. On endothelial cells lectin-like oxidized low density lipoprotein receptor 1 (LOX-1)
and scavenger receptor class B, type I (SR-BI), act in concert by mediating the holoparticle of
and selective cholesteryl ester uptake from HOCl-HDL. We therefore investigated the ligand …
myeloperoxidase-H 2 O 2-chloride system of activated phagocytes, alters the physiological
properties of high density lipoprotein (HDL) by generating a proatherogenic lipoprotein
particle. On endothelial cells lectin-like oxidized low density lipoprotein receptor 1 (LOX-1)
and scavenger receptor class B, type I (SR-BI), act in concert by mediating the holoparticle of
and selective cholesteryl ester uptake from HOCl-HDL. We therefore investigated the ligand …