[HTML][HTML] Selective modification of apoB-100 in the oxidation of low density lipoproteins by myeloperoxidase in vitro
C Yang, ZW Gu, M Yang, SN Lin, AJ Garcia-Prats… - Journal of lipid …, 1999 - ASBMB
Oxidative modification of LDL may be important in the initiation and/or progression of
atherosclerosis, but the precise mechanisms through which low density lipoprotein (LDL) is
oxidized are unknown. Recently, evidence for the existence of HOCl-oxidized LDL in human
atherosclerotic lesions has been reported, and myeloperoxidase (MPO), which is thought to
act through production of HOCl, has been identified in human atherosclerotic lesions. In the
present report we describe the formation of 2, 4-dinitrophenylhydrazine (DNPH)-reactive …
atherosclerosis, but the precise mechanisms through which low density lipoprotein (LDL) is
oxidized are unknown. Recently, evidence for the existence of HOCl-oxidized LDL in human
atherosclerotic lesions has been reported, and myeloperoxidase (MPO), which is thought to
act through production of HOCl, has been identified in human atherosclerotic lesions. In the
present report we describe the formation of 2, 4-dinitrophenylhydrazine (DNPH)-reactive …