[HTML][HTML] Eosinophil peroxidase nitrates protein tyrosyl residues: implications for oxidative damage by nitrating intermediates in eosinophilic inflammatory disorders
W Wu, Y Chen, SL Hazen - Journal of Biological Chemistry, 1999 - ASBMB
Eosinophil peroxidase (EPO) has been implicated in promoting oxidative tissue injury in
conditions ranging from asthma and other allergic inflammatory disorders to cancer and
parasitic/helminthic infections. Studies thus far on this unique peroxidase have primarily
focused on its unusual substrate preference for bromide (Br−) and the pseudohalide
thiocyanate (SCN−) forming potent hypohalous acids as cytotoxic oxidants. However, the
ability of EPO to generate reactive nitrogen species has not yet been reported. We now …
conditions ranging from asthma and other allergic inflammatory disorders to cancer and
parasitic/helminthic infections. Studies thus far on this unique peroxidase have primarily
focused on its unusual substrate preference for bromide (Br−) and the pseudohalide
thiocyanate (SCN−) forming potent hypohalous acids as cytotoxic oxidants. However, the
ability of EPO to generate reactive nitrogen species has not yet been reported. We now …