Teratogenic compounds of Veratrum californicum (Durand). XIV. Limb deformities produced by cyclopamine
RF Keeler - Proceedings of the Society for Experimental …, 1973 - journals.sagepub.com
RF Keeler
Proceedings of the Society for Experimental Biology and Medicine, 1973•journals.sagepub.comFour major alkaloids isolated from Veratrum californicum—veratramine, veratrosine,
cyclopamine, and muldamine—were fed to pregnant ewes during the fifth week of gestation.
Cyclopamine, when administered during Days 28, 29, and 30 of gestation, produced the
same congenital deformities of limbs previously produced by whole plants. These
deformities included shortening of the metacarpal or metatarsal bones.
cyclopamine, and muldamine—were fed to pregnant ewes during the fifth week of gestation.
Cyclopamine, when administered during Days 28, 29, and 30 of gestation, produced the
same congenital deformities of limbs previously produced by whole plants. These
deformities included shortening of the metacarpal or metatarsal bones.
Summary
Four major alkaloids isolated from Veratrum californicum—veratramine, veratrosine, cyclopamine, and muldamine— were fed to pregnant ewes during the fifth week of gestation. Cyclopamine, when administered during Days 28, 29, and 30 of gestation, produced the same congenital deformities of limbs previously produced by whole plants. These deformities included shortening of the metacarpal or metatarsal bones.
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