[HTML][HTML] Regulation of the murine Nfatc1 gene by NFATc2
B Zhou, RQ Cron, B Wu, A Genin, Z Wang, S Liu… - Journal of Biological …, 2002 - ASBMB
NFAT proteins play a key role in the inducible expression of cytokine genes in T
lymphocytes. NFATc1 and NFATc2 are the predominant NFAT family members in the
peripheral immune system. NFATc2 is found abundantly in the cytoplasm of resting T cells,
whereasNfatc1 expression is induced during T cell activation. To investigate Nfatc1
regulation, we characterized the structure of the murine Nfatc1 gene and its 5′-flanking
region. A 290-bp sequence proximal to the transcription start site is highly conserved …
lymphocytes. NFATc1 and NFATc2 are the predominant NFAT family members in the
peripheral immune system. NFATc2 is found abundantly in the cytoplasm of resting T cells,
whereasNfatc1 expression is induced during T cell activation. To investigate Nfatc1
regulation, we characterized the structure of the murine Nfatc1 gene and its 5′-flanking
region. A 290-bp sequence proximal to the transcription start site is highly conserved …