[HTML][HTML] Isolation of MEK5 and differential expression of alternatively spliced forms
JM English, CA Vanderbilt, S Xu, S Marcus… - Journal of Biological …, 1995 - ASBMB
The prototype mitogen-activated protein (MAP) kinase module is a three-kinase cascade
consisting of the MAP kinase, extracellular signal-regulated protein kinase (ERK) 1 or ERK2,
the MAP/ERK kinase (MEK) MEK1 or MEK2, and the MEK kinase, Raf-1 or B-Raf. This and
other MAP kinase modules are thought to be critical signal transducers in major cellular
events including proliferation, differentiation, and stress responses. To identify novel
mammalian MAP kinase modules, polymerase chain reaction was used to isolate a new …
consisting of the MAP kinase, extracellular signal-regulated protein kinase (ERK) 1 or ERK2,
the MAP/ERK kinase (MEK) MEK1 or MEK2, and the MEK kinase, Raf-1 or B-Raf. This and
other MAP kinase modules are thought to be critical signal transducers in major cellular
events including proliferation, differentiation, and stress responses. To identify novel
mammalian MAP kinase modules, polymerase chain reaction was used to isolate a new …
