WHEN burns are so extensive that skin grafts obtainable from remaining donor sites are insufficient to provide wound coverage, a new source of autograft must be found. Human epidermal cells from a small skin-biopsy sample can be cultured to produce coherent epithelial sheets sufficient to cover the entire body surface.^1,2 When this epithelium was applied to wounds on athymic mice it generated a human epidermis.³ Autologous cultured epithelium placed on small burn wounds in adults'¹ and children⁵ adhered and generated a permanent epidermis similar to that resulting from split-thickness skin grafts. We report here that in two children who sustained . . .