The extracellular matrix has a complex structure which provides the scaffold of the
connective tissue and influences many cellular functions. Fibroblast attachment, chemotaxis,
and proliferation depend on the interaction of the cells with different components of the
extracellular matrix. In addition, biosynthetic activities including protein and collagen
synthesis are regulated by a two-or three-dimensional contact of fibroblasts with the
surrounding matrix. Since scleroderma is characterized by an excessive deposition of …