[HTML][HTML] Oncostatin M stimulates transcription of the human α2 (I) collagen gene via the Sp1/Sp3-binding site
H Ihn, EC LeRoy, M Trojanowska - Journal of Biological Chemistry, 1997 - ASBMB
Oncostatin M (OSM), a member of the hematopoietic cytokine family, has been implicated in
excessive bone growth and in the process of fibrosis. As part of an ongoing study of the
molecular mechanisms of fibrosis, we have investigated the transcriptional regulation of the
α2 (I) collagen gene by OSM in human fibroblasts. An OSM response element was mapped
by deletional analysis between base pairs (bp)− 148 and− 108 in the α2 (I) collagen
promoter. Further functional analysis of the α2 (I) collagen promoter containing various …
excessive bone growth and in the process of fibrosis. As part of an ongoing study of the
molecular mechanisms of fibrosis, we have investigated the transcriptional regulation of the
α2 (I) collagen gene by OSM in human fibroblasts. An OSM response element was mapped
by deletional analysis between base pairs (bp)− 148 and− 108 in the α2 (I) collagen
promoter. Further functional analysis of the α2 (I) collagen promoter containing various …