Hyperoxic lung injury: Biochemical cellular, and morphologic characterization in the mouse
LJ Smith - The Journal of laboratory and clinical medicine, 1985 - translationalres.com
Controversy exists over the mechanism by which oxygen produces lung damage. This study
was designed to characterize the biochemical, cellular, and morphologic responses of mice
exposed to 100% oxygen and thereby provide the basis for investigating the mechanisms
producing the lung damage as well as for evaluating treatment strategies. After 1 day of
exposure, plasma lactate dehydrogenase (LDH) activity and LDH isoenzyme 1, 2, and 3
concentration increased, whereas the level of isoenzyme 1 recovered from the lung, heart …
was designed to characterize the biochemical, cellular, and morphologic responses of mice
exposed to 100% oxygen and thereby provide the basis for investigating the mechanisms
producing the lung damage as well as for evaluating treatment strategies. After 1 day of
exposure, plasma lactate dehydrogenase (LDH) activity and LDH isoenzyme 1, 2, and 3
concentration increased, whereas the level of isoenzyme 1 recovered from the lung, heart …