1. More than 1300 coumarins have been identified from natural sources, especially green
plants. The pharmacological and biochemical properties and therapeutic applications of
simple coumarins depend upon the pattern of substitution. More complex related
compounds based on the coumarin nucleus include the dicoumarol/warfarin anticoagulants,
aflatoxins and the psoralens (photosensitizing agents). 2. 2. Coumarin itself (1, 2-
benzopyrone) has long-established efficacy in slow-onset long-term reduction of …