Enhanced mutational activity of Vκ gene rearrangements in systemic lupus erythematosus
To determine the differential impact of somatic hypermutation and selective influences on
the light chain repertoire in systemic lupus erythematosus (SLE), the frequency and pattern
of somatic hypermutations were compared between the productive and nonproductive Vκ
gene repertoire manifested by individual CD19+ B cells in a patient with SLE. The
mutational frequency of nonproductive rearrangements in the SLE patient was significantly
(P< 0.001) increased (3.7× 10− 2) compared to normals (4.8× 10− 3). Similarly, the …
the light chain repertoire in systemic lupus erythematosus (SLE), the frequency and pattern
of somatic hypermutations were compared between the productive and nonproductive Vκ
gene repertoire manifested by individual CD19+ B cells in a patient with SLE. The
mutational frequency of nonproductive rearrangements in the SLE patient was significantly
(P< 0.001) increased (3.7× 10− 2) compared to normals (4.8× 10− 3). Similarly, the …