Inhibition of renin–angiotensin system attenuates liver enzyme-altered preneoplastic lesions and fibrosis development in rats
H Yoshiji, J Yoshii, Y Ikenaka, R Noguchi… - Journal of …, 2002 - Elsevier
Background/Aims: It is suggested that the renin–angiotensin system (RAS) is involved in
tumor development and fibrogenesis. The aim of the present study was to examine the effect
of RAS inhibition on the liver enzyme-altered preneoplastic lesions and fibrosis
development. Methods: The effects of the clinically used angiotensin-I converting enzyme
inhibitor (ACE-I), perindopril (PE), on two different rat model of liver carcinogenesis models
induced separately by diethylnitrosamine (DEN) and a choline-deficient l-amino acid …
tumor development and fibrogenesis. The aim of the present study was to examine the effect
of RAS inhibition on the liver enzyme-altered preneoplastic lesions and fibrosis
development. Methods: The effects of the clinically used angiotensin-I converting enzyme
inhibitor (ACE-I), perindopril (PE), on two different rat model of liver carcinogenesis models
induced separately by diethylnitrosamine (DEN) and a choline-deficient l-amino acid …