Reactive oxygen species as mediators of angiotensin II signaling

KK Griendling, M Ushio-Fukai - Regulatory peptides, 2000 - Elsevier
Angiotensin II stimulates a plethora of signaling pathways leading to cell growth and
contraction. Recent work has shown that reactive oxygen species are involved in
transducing many of the effects of angiotensin II, and are in fact produced in response to
agonist-receptor binding. Angiotensin II stimulates a NAD (P) H oxidase to produce
superoxide and hydrogen peroxide, both of which may act on intracellular growth-related
proteins and enzymes to mediate the final physiological response. Of particular importance …