N-acetylcysteine induces cell cycle arrest in hepatic stellate cells through its reducing activity
KY Kim, TY Rhim, I Choi, SS Kim - Journal of Biological Chemistry, 2001 - ASBMB
Activation of hepatic stellate cells (HSC) has been identified as a critical step in hepatic
fibrogenesis and is regulated by several factors including cytokines and oxidative stress.
However, the molecular mechanism for HSC inactivation is not well understood. We
investigated anN-acetyl-l-cysteine (NAC)-mediated signaling pathway involved in HSC
inactivation. NAC, which acting through its reducing activity, induced cell arrest at G 1 via the
mitogen-activated protein kinase (MAPK) kinase (MEK)/MAPK pathway in a Ras …
fibrogenesis and is regulated by several factors including cytokines and oxidative stress.
However, the molecular mechanism for HSC inactivation is not well understood. We
investigated anN-acetyl-l-cysteine (NAC)-mediated signaling pathway involved in HSC
inactivation. NAC, which acting through its reducing activity, induced cell arrest at G 1 via the
mitogen-activated protein kinase (MAPK) kinase (MEK)/MAPK pathway in a Ras …
