High-dose immunosuppression and hematopoietic stem cell transplantation in autoimmune disease: clinical review
H Openshaw, RA Nash… - Biology of Blood and …, 2002 - tctjournal.org
Since 1996, a number of investigators have carried out phase I-II studies of high-dose
immunosuppression with autologous hematopoietic stem cell transplantation (HSCT) in
autoimmune diseases. Most of this activity has been in studies of multiple sclerosis (MS),
systemic sclerosis (SSc), systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), and
juvenile idiopathic arthritis (JIA). Supported by animal models of antigen-induced
autoimmunity, the rationale of HSCT is to time-shift the clinical autoimmunity to an earlier …
immunosuppression with autologous hematopoietic stem cell transplantation (HSCT) in
autoimmune diseases. Most of this activity has been in studies of multiple sclerosis (MS),
systemic sclerosis (SSc), systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), and
juvenile idiopathic arthritis (JIA). Supported by animal models of antigen-induced
autoimmunity, the rationale of HSCT is to time-shift the clinical autoimmunity to an earlier …
