[HTML][HTML] Tolerance and hematopoietic stem cell transplantation 50 years after Burnet's theory
F Locatelli, D Rondelli, GR Burgio - Experimental hematology, 2000 - Elsevier
OBJECTIVE: In 1949, the original formulation of Burnet's theory on the mechanisms
responsible for the capacity of the immune system to discriminate between foreign antigens
(ie, the “non-self”) and the cells of its own body (ie, the “self”) was published. Since then,
further refinements and reconsiderations of the basic concepts underlying the achievement
of a state of tolerance toward a certain antigen have been reported. Here, we attempt to
analyze critically new clinical and experimental strategies aimed at inducing alloantigen …
responsible for the capacity of the immune system to discriminate between foreign antigens
(ie, the “non-self”) and the cells of its own body (ie, the “self”) was published. Since then,
further refinements and reconsiderations of the basic concepts underlying the achievement
of a state of tolerance toward a certain antigen have been reported. Here, we attempt to
analyze critically new clinical and experimental strategies aimed at inducing alloantigen …
