The molecular basis of thyroid hormone action
GA Brent - New England Journal of Medicine, 1994 - Mass Medical Soc
GA Brent
New England Journal of Medicine, 1994•Mass Medical SocThyroid hormone exerts a broad range of effects on development, growth, and metabolism.
The clinical manifestations of thyroid hormone excess and deficiency are dramatic examples
of the myriad actions of the hormone. Thyroxine (T4), the primary secretory product of the
thyroid, is relatively inactive and is converted to the active hormone, triiodothyronine (T3), by
the enzyme thyroxine 5'-deiodinase (Figure 1) 1. The actions of thyroid hormone are
primarily the result of the interaction of T3 with nuclear receptors for T3 that bind to …
The clinical manifestations of thyroid hormone excess and deficiency are dramatic examples
of the myriad actions of the hormone. Thyroxine (T4), the primary secretory product of the
thyroid, is relatively inactive and is converted to the active hormone, triiodothyronine (T3), by
the enzyme thyroxine 5'-deiodinase (Figure 1) 1. The actions of thyroid hormone are
primarily the result of the interaction of T3 with nuclear receptors for T3 that bind to …
Thyroid hormone exerts a broad range of effects on development, growth, and metabolism. The clinical manifestations of thyroid hormone excess and deficiency are dramatic examples of the myriad actions of the hormone. Thyroxine (T4), the primary secretory product of the thyroid, is relatively inactive and is converted to the active hormone, triiodothyronine (T3), by the enzyme thyroxine 5'-deiodinase (Figure 1)1. The actions of thyroid hormone are primarily the result of the interaction of T3 with nuclear receptors for T3 that bind to regulatory regions of genes (thyroid hormone-response elements) and modify their expression . . .
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