• Fifty patients with gram-negative lower respiratory tract infections were treated with
intravenous ciprofloxacin to evaluate efficacy and safety. Relationships between individual
pharmacokinetics and clinical and bacteriologic outcome were studied. Ciprofloxacin
concentrations in plasma were determined by high-performance liquid chromatography.
Respiratory secretion cultures were obtained daily to determine the eradication day of the
infecting organism. Susceptibility (minimum inhibitory concentration) to ciprofloxacin and …