[HTML][HTML] Scaffold role of a mitogen-activated protein kinase phosphatase, SKRP1, for the JNK signaling pathway
T Zama, R Aoki, T Kamimoto, K Inoue, Y Ikeda… - Journal of Biological …, 2002 - ASBMB
Stress-activated protein kinase (SAPK) pathway-regulating phosphatase 1 (SKRP1) has
been identified as a member of the mitogen-activated protein kinase (MAPK) phosphatase
(MKP) family that interacts physically with the MAPK kinase (MAPKK) MKK7, a c-Jun N-
terminal kinase (JNK) activator, and inactivates the MAPK JNK pathway. Although these
findings indicated that SKRP1 contributes to the precise regulation of JNK signaling, it
remains to be elucidated how SKRP1 is integrated into this pathway. We report that SKRP1 …
been identified as a member of the mitogen-activated protein kinase (MAPK) phosphatase
(MKP) family that interacts physically with the MAPK kinase (MAPKK) MKK7, a c-Jun N-
terminal kinase (JNK) activator, and inactivates the MAPK JNK pathway. Although these
findings indicated that SKRP1 contributes to the precise regulation of JNK signaling, it
remains to be elucidated how SKRP1 is integrated into this pathway. We report that SKRP1 …