[HTML][HTML] Activation of the p38 signaling pathway by heat shock involves the dissociation of glutathione S-transferase Mu from Ask1
S Dorion, H Lambert, J Landry - Journal of Biological Chemistry, 2002 - ASBMB
Despite the importance of the stress-activated protein kinase pathways in cell death and
survival, it is unclear how stressful stimuli lead to their activation. In the case of heat shock,
the existence of a specific mechanism of activation has been evidenced, but the molecular
nature of this pathway is undefined. Here, we found that Ask1 (apoptosis signal-regulating
kinase 1), an upstream activator of the stress-activated protein kinase p38 during exposure
to oxidative stress and other stressful stimuli, was also activated by heat shock. Ask1 activity …
survival, it is unclear how stressful stimuli lead to their activation. In the case of heat shock,
the existence of a specific mechanism of activation has been evidenced, but the molecular
nature of this pathway is undefined. Here, we found that Ask1 (apoptosis signal-regulating
kinase 1), an upstream activator of the stress-activated protein kinase p38 during exposure
to oxidative stress and other stressful stimuli, was also activated by heat shock. Ask1 activity …