[HTML][HTML] Role of glutaredoxin in metabolic oxidative stress: glutaredoxin as a sensor of oxidative stress mediated by H2O2
JJ Song, JG Rhee, M Suntharalingam, SA Walsh… - Journal of Biological …, 2002 - ASBMB
Epitope-tagged glutaredoxin (GRX) was utilized to determine the role of GRX in oxidative
stress-induced signaling and cytotoxicity in glucose-deprived human cancer cells (MCF-
7/ADR and DU-145). GRX-overexpressing cells demonstrated resistance to glucose
deprivation-induced cytotoxicity and decreased activation of c-Jun N-terminal kinase (JNK1).
Deletion mutants showed the C-terminal portion of apoptosis signal-regulating kinase 1
(ASK1) bound GRX, and glucose deprivation disrupted binding. Treatment withl-buthionine …
stress-induced signaling and cytotoxicity in glucose-deprived human cancer cells (MCF-
7/ADR and DU-145). GRX-overexpressing cells demonstrated resistance to glucose
deprivation-induced cytotoxicity and decreased activation of c-Jun N-terminal kinase (JNK1).
Deletion mutants showed the C-terminal portion of apoptosis signal-regulating kinase 1
(ASK1) bound GRX, and glucose deprivation disrupted binding. Treatment withl-buthionine …