Amino acid and cDNA sequences of a vascular endothelial cell mitogen that is homologous to platelet-derived growth factor.
G Conn, ML Bayne, DD Soderman… - Proceedings of the …, 1990 - National Acad Sciences
G Conn, ML Bayne, DD Soderman, PW Kwok, KA Sullivan, TM Palisi, DA Hope, KA Thomas
Proceedings of the National Academy of Sciences, 1990•National Acad SciencesGlioma-derived vascular endothelial cell growth factor (GD-VEGF) is a 46-kDa dimeric
glycoprotein mitogen with apparently greater specificity for vascular endothelial cells than
the well-characterized fibroblast growth factors. The GD-VEGF cDNA sequence encodes a
190-amino acid residue subunit that is converted, by removal of an amino-terminal
hydrophobic secretory leader sequence, to the mature 164-residue subunit characterized by
direct amino acid sequencing. The GD-VEGF homodimeric subunit is homologous to the …
glycoprotein mitogen with apparently greater specificity for vascular endothelial cells than
the well-characterized fibroblast growth factors. The GD-VEGF cDNA sequence encodes a
190-amino acid residue subunit that is converted, by removal of an amino-terminal
hydrophobic secretory leader sequence, to the mature 164-residue subunit characterized by
direct amino acid sequencing. The GD-VEGF homodimeric subunit is homologous to the …
Glioma-derived vascular endothelial cell growth factor (GD-VEGF) is a 46-kDa dimeric glycoprotein mitogen with apparently greater specificity for vascular endothelial cells than the well-characterized fibroblast growth factors. The GD-VEGF cDNA sequence encodes a 190-amino acid residue subunit that is converted, by removal of an amino-terminal hydrophobic secretory leader sequence, to the mature 164-residue subunit characterized by direct amino acid sequencing. The GD-VEGF homodimeric subunit is homologous to the platelet-derived growth factor A and B chains and its oncogene homologue v-sis.
National Acad Sciences
