[HTML][HTML] Signaling by the germinal center kinase family of protein kinases
JM Kyriakis - Journal of Biological Chemistry, 1999 - ASBMB
Mammalian mitogen-activated protein kinase (MAPK) 1 pathways regulate an extensive
range of cellular processes including gene transcription, cytoskeletal organization,
metabolite homeostasis, cell growth, and apoptosis. At the physiologic level, MAPK
pathways are likely to be critical to the pathogenesis of a number of important clinical
conditions including oncogenesis, diabetes, ischemic injury, arthritis, and septic shock.
MAPK pathways have been widely conserved in eukaryotic cell evolution. At the heart of …
range of cellular processes including gene transcription, cytoskeletal organization,
metabolite homeostasis, cell growth, and apoptosis. At the physiologic level, MAPK
pathways are likely to be critical to the pathogenesis of a number of important clinical
conditions including oncogenesis, diabetes, ischemic injury, arthritis, and septic shock.
MAPK pathways have been widely conserved in eukaryotic cell evolution. At the heart of …