[HTML][HTML] Temperature-sensitive differential affinity of TRAIL for its receptors: DR5 is the highest affinity receptor
A Truneh, S Sharma, C Silverman, S Khandekar… - Journal of Biological …, 2000 - ASBMB
TRAIL is a member of the tumor necrosis factor (TNF) family of cytokines which induces
apoptotic cell death in a variety of tumor cell lines. It mediates its apoptotic effects through
one of two receptors, DR4 and DR5, which are members of of the TNF receptor family, and
whose cytoplasmic regions contain death domains. In addition, TRAIL also binds to 3"
decoy" receptors, DcR2, a receptor with a truncated death domain, DcR1, a
glycosylphosphatidylinositol-anchored receptor, and OPG a secreted protein which is also …
apoptotic cell death in a variety of tumor cell lines. It mediates its apoptotic effects through
one of two receptors, DR4 and DR5, which are members of of the TNF receptor family, and
whose cytoplasmic regions contain death domains. In addition, TRAIL also binds to 3"
decoy" receptors, DcR2, a receptor with a truncated death domain, DcR1, a
glycosylphosphatidylinositol-anchored receptor, and OPG a secreted protein which is also …