[HTML][HTML] Heparan sulfate-modified CD44 promotes hepatocyte growth factor/scatter factor-induced signal transduction through the receptor tyrosine kinase c-Met
R van der Voort, TEI Taher, VJM Wielenga… - Journal of Biological …, 1999 - ASBMB
CD44 has been implicated in tumor progression and metastasis, but the mechanism (s)
involved is as yet poorly understood. Recent studies have shown that CD44 isoforms
containing the alternatively spliced exon v3 carry heparan sulfate side chains and are able
to bind heparin-binding growth factors. In the present study, we have explored the possibility
of a physical and functional interaction between CD44 and hepatocyte growth factor/scatter
factor (HGF/SF), the ligand of the receptor tyrosine kinase c-Met. The HGF/SF-c-Met pathway …
involved is as yet poorly understood. Recent studies have shown that CD44 isoforms
containing the alternatively spliced exon v3 carry heparan sulfate side chains and are able
to bind heparin-binding growth factors. In the present study, we have explored the possibility
of a physical and functional interaction between CD44 and hepatocyte growth factor/scatter
factor (HGF/SF), the ligand of the receptor tyrosine kinase c-Met. The HGF/SF-c-Met pathway …