The role of Fas ligand in immune privilege
DR Green, TA Ferguson - Nature reviews Molecular cell biology, 2001 - nature.com
Nature reviews Molecular cell biology, 2001•nature.com
Immune privilege is a property of some sites in the body, whereby immune responses are
limited or prevented. One explanation that has been proposed for this phenomenon is
engagement of the pro-apoptotic molecule Fas by its ligand (FasL), which leads to
apoptosis, and consequently limits an inflammatory response. This idea has recently been
challenged, and here we review the evidence for and against a role for FasL in immune
privilege.
limited or prevented. One explanation that has been proposed for this phenomenon is
engagement of the pro-apoptotic molecule Fas by its ligand (FasL), which leads to
apoptosis, and consequently limits an inflammatory response. This idea has recently been
challenged, and here we review the evidence for and against a role for FasL in immune
privilege.
Abstract
Immune privilege is a property of some sites in the body, whereby immune responses are limited or prevented. One explanation that has been proposed for this phenomenon is engagement of the pro-apoptotic molecule Fas by its ligand (FasL), which leads to apoptosis, and consequently limits an inflammatory response. This idea has recently been challenged, and here we review the evidence for and against a role for FasL in immune privilege.
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