Physiologic responses to small emboli and hemodynamic effects of changes in deformability of polymorphonuclear leukocytes in isolated rabbit lung
H Tanaka, M Nishino, TE Dahms - Microvascular research, 2002 - Elsevier
We hypothesized that polymorphonuclear leukocytes (PMNs) exposed to lipopolysaccharide
(LPS) or chemotactic peptide N-formyl-l-methionyl-l-leucyl-l-phenylalanine (FMLP) would
alter the pulmonary hemodynamics of buffer-perfused rabbit lung. Pulmonary arterial
pressure (Ppa) was measured at baseline, at peak response, and at 30 min after PMN
infusion in the perfusate (Ppa× time, PT product). Infusion of peritoneal-harvested PMNs
resulted in a transient increase in both pulmonary vascular resistance (PVR) and lung …
(LPS) or chemotactic peptide N-formyl-l-methionyl-l-leucyl-l-phenylalanine (FMLP) would
alter the pulmonary hemodynamics of buffer-perfused rabbit lung. Pulmonary arterial
pressure (Ppa) was measured at baseline, at peak response, and at 30 min after PMN
infusion in the perfusate (Ppa× time, PT product). Infusion of peritoneal-harvested PMNs
resulted in a transient increase in both pulmonary vascular resistance (PVR) and lung …