[HTML][HTML] Extracellular signal-regulated kinase plays an essential role in hypertrophic agonists, endothelin-1 and phenylephrine-induced cardiomyocyte hypertrophy
TL Yue, JL Gu, C Wang, AA Parsons… - Journal of Biological …, 2000 - ASBMB
The extracellular signal-regulated kinase (ERK) pathway is activated by hypertrophic stimuli
in cardiomyocytes. However, whether ERK plays an essential role or is implicated in all
major components of cardiac hypertrophy remains controversial. Using a selective MEK
inhibitor, U0126, and a selective Raf inhibitor, SB-386023, to block the ERK signaling
pathway at two different levels and adenovirus-mediated transfection of dominant-negative
Raf, we studied the role of ERK signaling in response of cultured rat cardiomyocytes to …
in cardiomyocytes. However, whether ERK plays an essential role or is implicated in all
major components of cardiac hypertrophy remains controversial. Using a selective MEK
inhibitor, U0126, and a selective Raf inhibitor, SB-386023, to block the ERK signaling
pathway at two different levels and adenovirus-mediated transfection of dominant-negative
Raf, we studied the role of ERK signaling in response of cultured rat cardiomyocytes to …