[HTML][HTML] A mutant form of JAB/SOCS1 augments the cytokine-induced JAK/STAT pathway by accelerating degradation of wild-type JAB/CIS family proteins through the …
T Hanada, T Yoshida, I Kinjyo, S Minoguchi… - Journal of Biological …, 2001 - ASBMB
Cytokines exert biological functions by activating Janus tyrosine kinases (JAKs), and JAK
inhibitors JAB (also referred to as SOCS1 and SSI1) and CIS3 (SOCS3) play an essential
role in the negative regulation of cytokine signaling. We have found that transgenic (Tg)
mice expressing a mutant JAB (F59D-JAB) exhibited a more potent STAT3 activation and a
more severe colitis than did wild-type littermates after treatment with dextran sulfate sodium.
We now find that there is a prolonged activation of JAKs and STATs in response to a number …
inhibitors JAB (also referred to as SOCS1 and SSI1) and CIS3 (SOCS3) play an essential
role in the negative regulation of cytokine signaling. We have found that transgenic (Tg)
mice expressing a mutant JAB (F59D-JAB) exhibited a more potent STAT3 activation and a
more severe colitis than did wild-type littermates after treatment with dextran sulfate sodium.
We now find that there is a prolonged activation of JAKs and STATs in response to a number …