Epstein-Barr virus is infrequently identified in non-Hodgkin's lymphomas associated with Hodgkin's disease
DW Kingma, LJ Medeiros, J Barletta… - The American journal …, 1994 - journals.lww.com
Epstein-Barr virus (EBV) was identified in a subset of cases of Hodgkin's disease (HD) and
in some non-Hodgkin's lymphomas (NHLs), particularly those associated with
immunodeficiency. Because patients with HD have associated immune system defects, we
hypothesized that EBV might be involved in NHLs associated with HD. Using fixed paraffin
sections and in situ hybridization for EBV EBER1 RNA, we studied 12 cases of composite
NHL+ HD, two patients with NHL who simultaneously also had HD involving a different site …
in some non-Hodgkin's lymphomas (NHLs), particularly those associated with
immunodeficiency. Because patients with HD have associated immune system defects, we
hypothesized that EBV might be involved in NHLs associated with HD. Using fixed paraffin
sections and in situ hybridization for EBV EBER1 RNA, we studied 12 cases of composite
NHL+ HD, two patients with NHL who simultaneously also had HD involving a different site …