[HTML][HTML] Nitric oxide activation of p38 mitogen-activated protein kinase in 293T fibroblasts requires cGMP-dependent protein kinase
DD Browning, MP McShane, C Marty… - Journal of Biological …, 2000 - ASBMB
An increase in cellular levels of cyclic nucleotides activates serine/threonine-dependent
kinases that lead to diverse physiological effects. Recently we reported the activation of the
p38 mitogen-activated protein kinase (MAPK) pathway in neutrophils by a cGMP-dependent
mechanism. In this study we demonstrated that exogenously supplied nitric oxide leads to
activation of p38 MAPK in 293T fibroblasts. Phosphorylation of p38 corresponded with an
increase in ATF-2-dependent gene expression. The effect of nitric oxide was mimicked by …
kinases that lead to diverse physiological effects. Recently we reported the activation of the
p38 mitogen-activated protein kinase (MAPK) pathway in neutrophils by a cGMP-dependent
mechanism. In this study we demonstrated that exogenously supplied nitric oxide leads to
activation of p38 MAPK in 293T fibroblasts. Phosphorylation of p38 corresponded with an
increase in ATF-2-dependent gene expression. The effect of nitric oxide was mimicked by …