Cytokines and JAK–STAT signaling
C Schindler - Experimental cell research, 1999 - Elsevier
C Schindler
Experimental cell research, 1999•ElsevierCharacterization of the ability of IFNs to induce immediate early genes led to the
identification of the STAT (signal transducers and activators of transcription) signaling
paradigm. STATs are activated at the receptor and then directly transduce signals to the
nucleus. Subsequent studies have determined that all cytokines transduce critical signals
through this pathway.
identification of the STAT (signal transducers and activators of transcription) signaling
paradigm. STATs are activated at the receptor and then directly transduce signals to the
nucleus. Subsequent studies have determined that all cytokines transduce critical signals
through this pathway.
Characterization of the ability of IFNs to induce immediate early genes led to the identification of the STAT (signal transducers and activators of transcription) signaling paradigm. STATs are activated at the receptor and then directly transduce signals to the nucleus. Subsequent studies have determined that all cytokines transduce critical signals through this pathway.
Elsevier
