Adhesion of human B cells to germinal centers in vitro involves VLA-4 and INCAM-110
AS Freedman, JM Munro, GE Rice, MP Bevilacqua… - Science, 1990 - science.org
AS Freedman, JM Munro, GE Rice, MP Bevilacqua, C Morimoto, BW McIntyre, K Rhynhart…
Science, 1990•science.orgHuman B lymphocytes localize and differentiate within the microenvironment of lymphoid
germinal centers. A frozen section binding assay was developed for the identification of
those molecules involved in the adhesive interactions between B cells and lymphoid
follicles. Activated human B cells and B cell lines were found to selectively adhere to
germinal centers. The VLA-4 molecule on the lymphocyte and the adhesion molecule
INCAM-110, expressed on follicular dendritic cells, supported this interaction. This cellular …
germinal centers. A frozen section binding assay was developed for the identification of
those molecules involved in the adhesive interactions between B cells and lymphoid
follicles. Activated human B cells and B cell lines were found to selectively adhere to
germinal centers. The VLA-4 molecule on the lymphocyte and the adhesion molecule
INCAM-110, expressed on follicular dendritic cells, supported this interaction. This cellular …
Human B lymphocytes localize and differentiate within the microenvironment of lymphoid germinal centers. A frozen section binding assay was developed for the identification of those molecules involved in the adhesive interactions between B cells and lymphoid follicles. Activated human B cells and B cell lines were found to selectively adhere to germinal centers. The VLA-4 molecule on the lymphocyte and the adhesion molecule INCAM-110, expressed on follicular dendritic cells, supported this interaction. This cellular interaction model can be used for the study of how B cells differentiate.
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