In addition to its participation in fibrinolysis, plasminogen is believed to play an important
role in mediating cell migration. The development of mice in which the plasminogen gene
has been inactivated (Plg−/− mice) has provided an opportunity to address the contributions
of plasminogen to cell migratory events in an in vivo setting. This article summarizes some
recent studies in which cell migration has been evaluated in the Plg−/− mice. In models of
inflammation; wound healing, both extravascular and intravascular; atherosclerosis; and …