Myasthenia gravis: demonstration of membrane attack complex in muscle end-plates.
A Fazekas, S Komoly, B Bózsik, A Szobor - Clinical neuropathology, 1986 - europepmc.org
A Fazekas, S Komoly, B Bózsik, A Szobor
Clinical neuropathology, 1986•europepmc.orgThe membrane attack complex (MAC) assembles from C5b-9 complement components and
has neoantigenic properties. Antihuman-MAC rabbit immunserum was applied in order to
localize the MAC in myasthenic muscles. Using the indirect immunoperoxidase method
MAC was demonstrated at the motor end-plates in eleven myasthenic patients who
underwent thymectomy. This result provides direct evidence of antibody-dependent
complement-mediated injury of acetylcholine receptors in myasthenia gravis.
has neoantigenic properties. Antihuman-MAC rabbit immunserum was applied in order to
localize the MAC in myasthenic muscles. Using the indirect immunoperoxidase method
MAC was demonstrated at the motor end-plates in eleven myasthenic patients who
underwent thymectomy. This result provides direct evidence of antibody-dependent
complement-mediated injury of acetylcholine receptors in myasthenia gravis.
The membrane attack complex (MAC) assembles from C5b-9 complement components and has neoantigenic properties. Antihuman-MAC rabbit immunserum was applied in order to localize the MAC in myasthenic muscles. Using the indirect immunoperoxidase method MAC was demonstrated at the motor end-plates in eleven myasthenic patients who underwent thymectomy. This result provides direct evidence of antibody-dependent complement-mediated injury of acetylcholine receptors in myasthenia gravis.
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