[HTML][HTML] CREB and its associated proteins act as survival factors for human melanoma cells
cAMP response element-binding protein (CREB) and activating transcription factor 1 (ATF-
1), members of the CREB/ATF family, have been implicated in cAMP-and calcium-induced
transcriptional activation. We have previously demonstrated that quenching of CREB-
associated proteins in metastatic melanoma cells by a dominant-negative CREB (KCREB)
that is mutated within its DNA-binding domain decreased their radiation resistance, and their
tumorigenic and metastatic potential in nude mice. As the induction of apoptosis by diverse …
1), members of the CREB/ATF family, have been implicated in cAMP-and calcium-induced
transcriptional activation. We have previously demonstrated that quenching of CREB-
associated proteins in metastatic melanoma cells by a dominant-negative CREB (KCREB)
that is mutated within its DNA-binding domain decreased their radiation resistance, and their
tumorigenic and metastatic potential in nude mice. As the induction of apoptosis by diverse …