DHEA and its transformation into androgens and estrogens in peripheral target tissues: intracrinology
F Labrie, V Luu-The, C Labrie, J Simard - Frontiers in neuroendocrinology, 2001 - Elsevier
A new understanding of the endocrinology of menopause is that women, at menopause, are
not only lacking estrogens resulting from cessation of ovarian activity but have also been
progressively deprived for a few years of androgens and some estrogens originating from
adrenal DHEA and androstenedione (4-dione). In fact, serum DHEA decreases by about
60% between the maximal levels seen at 30 years of age to the age of menopause. This
decreased secretion of DHEA and DHEA-S by the adrenals is responsible for a parallel …
not only lacking estrogens resulting from cessation of ovarian activity but have also been
progressively deprived for a few years of androgens and some estrogens originating from
adrenal DHEA and androstenedione (4-dione). In fact, serum DHEA decreases by about
60% between the maximal levels seen at 30 years of age to the age of menopause. This
decreased secretion of DHEA and DHEA-S by the adrenals is responsible for a parallel …
