[HTML][HTML] Nuclear signaling by endothelin-1: a Ras pathway for activation of the c-fos serum response element
WH Herman, MS Simonson - Journal of Biological Chemistry, 1995 - ASBMB
Endothelin-1 (ET-1) regulates gene expression and growth of vascular cells by triggering
signals that link its cognate, G protein-coupled receptor in the plasma membrane to
transcriptional activation of immediate early genes in the nucleus. To define the nature of
these signals, we asked whether Ras proteins contribute to activation of the c-fos serum
response element (SRE) by ET-1 in mesangial cells, a microvascular cell from the renal
glomerulus. ET-1 stimulated Ras by increasing Ras GTP loading. Addition of ET-1 or …
signals that link its cognate, G protein-coupled receptor in the plasma membrane to
transcriptional activation of immediate early genes in the nucleus. To define the nature of
these signals, we asked whether Ras proteins contribute to activation of the c-fos serum
response element (SRE) by ET-1 in mesangial cells, a microvascular cell from the renal
glomerulus. ET-1 stimulated Ras by increasing Ras GTP loading. Addition of ET-1 or …