[HTML][HTML] Vascular Smooth Muscle Cell-derived, Gla-containing Growth-potentiating Factor for Ca2+-mobilizing Growth Factors (∗)
T Nakano, K Higashino, N Kikuchi, J Kishino… - Journal of Biological …, 1995 - ASBMB
Proliferation of vascular smooth muscle cells (VSMC) is triggered by two types of growth
factors. One activates tyrosine kinase-type receptors and the other activates G-protein-
coupled receptors. We found that a conditioned medium of rat VSMC contained a growth-
potentiating activity for the latter type of growth factor, and we purified a 70-kDa growth-
potentiating factor (GPF) from the conditioned medium. Analyses of GPF and its cDNA
revealed GPF to be a γ-carboxyglutamic acid-containing protein encoded by a growth arrest …
factors. One activates tyrosine kinase-type receptors and the other activates G-protein-
coupled receptors. We found that a conditioned medium of rat VSMC contained a growth-
potentiating activity for the latter type of growth factor, and we purified a 70-kDa growth-
potentiating factor (GPF) from the conditioned medium. Analyses of GPF and its cDNA
revealed GPF to be a γ-carboxyglutamic acid-containing protein encoded by a growth arrest …